硝酸 
中文同義詞: (2,4-二氯基)-2-[(2,4-二氯基)甲氧基]乙基]-1H-咪唑硝酸鹽;達克寧;美康唑;密康唑;雙氯咪唑;酶康唑;硝酸氯 
英文名稱: Miconazole nitrate 
英文同義詞: 1-[2,4-DICHLORO BETA-[2,4-DICHLOROBENZYL]OXY]-PHENETHYL]IMIDAZOLE NITRATE;1-[2,4-DICHLORO-BETA-([2,4-DICHLOROBENZYL]OXY)-PHENETHYL]IMIDAZOLE NITRATE SALT;1-[2-(2,4-DICHLOROBENZYLOXY)-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE NITRATE;LABOTEST-BB LT00134678;(+/-)MICONAZOLE NITRATE SALT;1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)-imidazolmononitra;1h-imidazole,1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl);daktacort 
CAS號: 22832-87-7 
分子式: C18H15Cl4N3O4 
分子量: 479.14 
EINECS號: 245-256-6 
相關類別: 原料藥;抗生素;抗菌，皮膚外用
性狀：該品為白色或類白色的結晶或結晶性粉末；無臭或幾乎無臭。該品在甲醇中略溶，在氯仿或中微溶，在水中不溶。    
標準：USP/BP 99%
用途：硝酸是人工合成的1-乙基咪唑衍生物，屬于咪唑類廣譜抗真菌藥物，就是我們熟悉的常用于治療皮膚癬的藥物達克寧，破壞細胞膜結構，使細胞膜的通透性增大，導致細胞內成份外泄并抑制葡萄糖的利用，阻止營養物攝取，終使真菌細胞死亡，適用于治療體癬、股癬、手癬、足癬、花斑癬以及真菌性甲溝炎和由酵母菌（如念珠菌等）和革蘭氏陽性細菌引起的陰道感染和繼發性感染,對外耳炎、細菌性皮膚感染也有效。
包裝：25KG紙板桶

Miconazole nitrate
Synonyms:1-[2,4-dichloro beta-[2,4-dichlorobenzyl]oxy]-phenethyl]imidazole nitrate;1-[2,4-dichloro-beta-([2,4-dichlorobenzyl]oxy)-phenethyl]imidazole nitrate salt;1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole nitrate;Labotest-bb lt00134678;(+/-)miconazole nitrate salt;1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)-imidazolmononitra;1h-imidazole,1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl);Daktacort
Cas:22832-87-7
Mf:C18h15cl4n3o4
Mw:479.14
Einecs:245-256-6
Product categories:Antifungals;Antifungal;Aromatics;Heterocycles;
Pharmaceuticals;Monistat
Chemical Properties:White Solid 
Assay:99%
Usage:Antifungal (topical).  An antifungal agent that inhibits platelet cyclooxygenase.
Biological Activity:Antifungal agent. Inhibits lanosterol demethylase and induces formation of reactive oxygen species. 
Packing:25kg/paper barrel


Test Items Specification Test Results
Appearance White or Almost white powder Complies
Identification IR Similar to standard Complies
Appearance of Solution The solution is clear and not more intensely cloured than reference solutions Complies
Solubility Very slightly soluble in water; soluble in methanol ; slightly soluble in alcohol Complies
Angle of optical rotation -0.1o～+0.1o Complies
Related Substances Each Impurity ≤0.25% 0.18%
Total Impurity ≤0.5% 0.25%
Melting Point 163～167℃ 164.5℃
Loss on Drying ≤0.5% 0.32%
Residue on Ignition ≤0.1% 0.01%

Assay (on dry basis) 98.0～102.0% 99.38%

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